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Vilitra 40 mg works by inhibiting the PDE-5 enzyme. This molecule is involved in achieving erection and it is destroyed by the PDE-5 enzyme when it comes into contact with it. Thus, Vilitra helps prolong an erection and maintain it for up to four hours. However, it is crucial to note that it will not work if you do not undergo sexual stimulation. This means that you need to engage in some sexual activity before you can take the medicine.